Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model

Abstract Background Proving that specific genes are essential for the intracellular viability of Leishmania parasites within macrophages remains a challenge for the identification of suitable targets for drug development. This is especially evident in the absence of a robust inducible expression sys...

Full description

Bibliographic Details
Main Authors: Daniel Paape, Catriona T. Prendergast, Helen P. Price, Johannes S. P. Doehl, Deborah F. Smith
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Parasites & Vectors
Subjects:
Leishmania
Plasmid shuffle
Mouse infection
Therapeutic target validation
Online Access:http://link.springer.com/article/10.1186/s13071-020-3999-1

Internet

http://link.springer.com/article/10.1186/s13071-020-3999-1

Similar Items