The Impact of Sphingosine Kinases on Inflammation-Induced Cytokine Release and Vascular Endothelial Barrier Integrity

The Impact of Sphingosine Kinases on Inflammation-Induced Cytokine Release and Vascular Endothelial Barrier Integrity

Sphingosine kinases type 1 and 2 (SphK1/2) are required for the production of the immune modulator sphingosine 1-phosphate (S1P). SphK1 deficient mice (SphK1<sup>−/−</sup>) revealed 50% reduced S1P in plasma, while SphK2<sup>−/−</sup> mice demonstrated 2–3 times increased S1P...

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Bibliographic Details
Main Authors: Andreas V. Thuy, Christina-Maria Reimann, Anke C. Ziegler, Markus H. Gräler
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
sphingosine 1-phosphate
dendritic cell
macrophage
sepsis
systemic infection
interferon-gamma
Online Access:https://www.mdpi.com/1422-0067/23/21/12848

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https://www.mdpi.com/1422-0067/23/21/12848

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