Purinergic exposure induces epigenomic and transcriptomic-mediated preconditioning resembling epilepsy-associated microglial states

Purinergic exposure induces epigenomic and transcriptomic-mediated preconditioning resembling epilepsy-associated microglial states

Summary: Microglia play a crucial role in a range of neuropathologies through exacerbated activation. Microglial inflammatory responses can be influenced by prior exposures to noxious stimuli, like increased levels of extracellular adenosine and ATP. These are characteristic of brain insults like ep...

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Bibliographic Details
Main Authors: Ricardo Martins-Ferreira, Josep Calafell-Segura, João Chaves, Laura Ciudad, António Martins da Silva, Paulo Pinho e Costa, Bárbara Leal, Esteban Ballestar
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:iScience
Subjects:
Microglia
Purines
Epilepsy
Epigenetics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224017711

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http://www.sciencedirect.com/science/article/pii/S2589004224017711

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