Unravelling the Role of PARP1 in Homeostasis and Tumorigenesis: Implications for Anti-Cancer Therapies and Overcoming Resistance

Unravelling the Role of PARP1 in Homeostasis and Tumorigenesis: Implications for Anti-Cancer Therapies and Overcoming Resistance

Detailing the connection between homeostatic functions of enzymatic families and eventual progression into tumorigenesis is crucial to our understanding of anti-cancer therapies. One key enzyme group involved in this process is the Poly (ADP-ribose) polymerase (PARP) family, responsible for an expan...

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Bibliographic Details
Main Authors: Taylor Lovsund, Fatemeh Mashayekhi, Amira Fitieh, James Stafford, Ismail Hassan Ismail
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
genome instability
DNA repair
PARP1
PARPi resistance
PARylation
homologous recombination
Online Access:https://www.mdpi.com/2073-4409/12/14/1904

Internet

https://www.mdpi.com/2073-4409/12/14/1904

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