Application of replication-defective West Nile virus vector to non-flavivirus vaccine targets

Application of replication-defective West Nile virus vector to non-flavivirus vaccine targets

The RepliVax vaccine platform(RV) is based on flavivirus genomes that are rationally attenuated by deletion. The self-limiting infection provided by RV has been demonstrated to be safe, highly immunogenic and efficacious for several vaccine candidates against flaviviruses. Here respiratory syncytial...

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Bibliographic Details
Main Authors: Maryann Giel-Moloney, Michael Vaine, Linong Zhang, Mark Parrington, Beata Gajewska, Thorsten U. Vogel, Svetlana O. Pougatcheva, Xiaochu Duan, Timothy Farrell, Irina Ustyugova, Sanjay Phogat, Harry Kleanthous, Konstantin V. Pugachev
Format: Article
Language:English
Published: Taylor & Francis Group 2017-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
non-flavivirus target
preclinical
replication-defective
replivax
vaccine vector
Online Access:http://dx.doi.org/10.1080/21645515.2017.1373920

Internet

http://dx.doi.org/10.1080/21645515.2017.1373920

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