Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions

Abstract Background Psychiatric medications are widely prescribed in the USA. Many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) signaling both induces cell differentiation and suppr...

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Bibliographic Details
Main Authors: A. N. Johnston, W. Bu, S. Hein, S. Garcia, L. Camacho, L. Xue, L. Qin, C. Nagi, S. G. Hilsenbeck, J. Kapali, K. Podsypanina, J. Nangia, Y. Li
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Breast Cancer Research
Subjects:
Cancer
Breast cancer
Antipsychotics
Neuroleptics
Prolactin
STAT5
Online Access:http://link.springer.com/article/10.1186/s13058-018-0969-z

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http://link.springer.com/article/10.1186/s13058-018-0969-z

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