Multisite phosphorylation of the guanine nucleotide exchange factor Cdc24 during yeast cell polarization.

BACKGROUND:Cell polarization is essential for processes such as cell migration and asymmetric cell division. A common regulator of cell polarization in most eukaryotic cells is the conserved Rho GTPase, Cdc42. In budding yeast, Cdc42 is activated by a single guanine nucleotide exchange factor, Cdc24...

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Bibliographic Details
Main Authors: Stephanie C Wai, Scott A Gerber, Rong Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2718613?pdf=render