Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration

Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration

Summary: Motor neuron (MN) demise is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Post-transcriptional gene regulation can control RNA’s fate, and defects in RNA processing are critical determinants of MN degeneration. N6-methyladenosine (m6A) is a...

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Bibliographic Details
Main Authors: Georgia Dermentzaki, Mattia Furlan, Iris Tanaka, Tommaso Leonardi, Paola Rinchetti, Patricia M.S. Passos, Alliny Bastos, Yuna M. Ayala, Jacob H. Hanna, Serge Przedborski, Dario Bonanomi, Mattia Pelizzola, Francesco Lotti
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724003279

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http://www.sciencedirect.com/science/article/pii/S2211124724003279

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