PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model

PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and fatal lung disease. In addition to dense fibrous tissue, abnormal angiogenesis is also an important feature of IPF. Pigment epithelium-derived factor (PEDF) is an angiogenesis inhibitor and a potential anti-fibrous...

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Bibliographic Details
Main Authors: Xichun Qin, Caili Jia, Jingtian Liang, Jiali Chen, Xiucheng Liu, Zhixiang Chao, Hao Qin, Yanliang Yuan, Zhiwei Liu, Zhongming Zhang, Hongyan Dong, Hao Zhang
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Respiratory Research
Subjects:
PEDF
IPF
Bleomycin
Fibroblast
PPAR-γ
Online Access:https://doi.org/10.1186/s12931-022-02027-4

Internet

https://doi.org/10.1186/s12931-022-02027-4

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