Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage

Abstract Midlobular hepatocytes are proposed to be the most plastic hepatic cell, providing a reservoir for hepatocyte proliferation during homeostasis and regeneration. However, other mechanisms beyond hyperplasia have been little explored and the contribution of other hepatocyte subpopulations to...

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Bibliographic Details
Main Authors: Inmaculada Ruz-Maldonado, John T. Gonzalez, Hanming Zhang, Jonathan Sun, Alicia Bort, Inamul Kabir, Richard G. Kibbey, Yajaira Suárez, Daniel M. Greif, Carlos Fernández-Hernando
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45439-0