Schlafen4+-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases

Schlafen4+-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases

IntroductionMDSCs express SCHLAFEN 4 (SLFN4) in Helicobacter-infected stomachs coincident with spasmolytic polypeptide-expressing metaplasia (SPEM), a precursor of gastric cancer. We aimed to characterize SLFN4+ cell identity and the role of Slfn4 in these cells.MethodsSingle-cell RNA sequencing was...

Full description

Bibliographic Details
Main Authors: Lin Ding, Sulaiman Sheriff, Ricky A. Sontz, Juanita L. Merchant
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
tumor microenvironment
single cell-RNA sequencing
GTPase
cGMP
sildenafil
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139391/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139391/full

Similar Items