Schlafen4+-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases

Schlafen4+-MDSC in Helicobacter-induced gastric metaplasia reveals role for GTPases

IntroductionMDSCs express SCHLAFEN 4 (SLFN4) in Helicobacter-infected stomachs coincident with spasmolytic polypeptide-expressing metaplasia (SPEM), a precursor of gastric cancer. We aimed to characterize SLFN4+ cell identity and the role of Slfn4 in these cells.MethodsSingle-cell RNA sequencing was...

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Bibliographic Details
Main Authors:	Lin Ding, Sulaiman Sheriff, Ricky A. Sontz, Juanita L. Merchant
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Immunology
Subjects:	tumor microenvironment single cell-RNA sequencing GTPase cGMP sildenafil
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139391/full

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