Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2

Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2

Yes-associated protein (YAP), the downstream effector of the evolutionarily conserved Hippo pathway, promotes cellular proliferation and coordinates certain regenerative responses in mammals. Small molecule activators of YAP may, therefore, display therapeutic utility in treating disease states invo...

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Bibliographic Details
Main Authors: Maya L Bulos, Edyta M Grzelak, Chloris Li-Ma, Emily Chen, Mitchell Hull, Kristen A Johnson, Michael J Bollong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-12-01
Series:eLife
Subjects:
YAP
regenerative medicine
alternative splicing
Online Access:https://elifesciences.org/articles/88508

Internet

https://elifesciences.org/articles/88508

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