A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies

A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies

Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence with a heterogeneous and complex pathophysiology that presents barriers to traditional targeted therapeutic approaches. We describe an integrated quantitative systems pharmacology (QSP) platform that comprehensively and unbiasedl...

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Bibliographic Details
Main Authors: Daniel E. Lefever, Mark T. Miedel, Fen Pei, Johanna K. DiStefano, Richard Debiasio, Tong Ying Shun, Manush Saydmohammed, Maria Chikina, Lawrence A. Vernetti, Alejandro Soto-Gutierrez, Satdarshan P. Monga, Ramon Bataller, Jaideep Behari, Vijay K. Yechoor, Ivet Bahar, Albert Gough, Andrew M. Stern, D. Lansing Taylor
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Metabolites
Subjects:
liver
non-alcoholic fatty liver disease
NAFLD
metabolic-associated fatty liver disease
MAFLD
microphysiology systems
Online Access:https://www.mdpi.com/2218-1989/12/6/528

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https://www.mdpi.com/2218-1989/12/6/528

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