Development and Characterization of Pituitary GH3 Cell Clones Stably Transfected with a Human Proinsulin cDNA

Development and Characterization of Pituitary GH3 Cell Clones Stably Transfected with a Human Proinsulin cDNA

Successful β-cell replacement therapy in insulin-dependent (type I) diabetes is hindered by the scarcity of human donor tissue and by the recurrence of autoimmune destruction of transplanted β cells. Availability of non-β cells, capable of releasing insulin and escaping autoimmune recognition, would...

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Main Authors: Cesare Meoni, Federico Bertuzzi, Antonio E. Pontiroli, Luca Falqui, Lucia Monaco, Marco Soria, Cinzia Arcelloni, Rita Paroni, Chiara Foglieni, Luca Polastri, Francesca Galbiati, Franco Folli, Alberto M. Davalli M.D.
Format: Article
Language:English
Published: SAGE Publishing 2000-11-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368970000900609

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https://doi.org/10.1177/096368970000900609

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