Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.

Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2.

The p90 ribosomal protein kinase 2 (RSK2) is a highly expressed Ser/Thr kinase activated by growth factors and is involved in cancer cell proliferation and tumor promoter-induced cell transformation. RSK2 possesses two non-identical kinase domains, and the structure of its N-terminal domain (NTD), w...

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Bibliographic Details
Main Authors: Margarita Malakhova, Igor Kurinov, Kangdong Liu, Duo Zheng, Igor D'Angelo, Jung-Hyun Shim, Valerie Steinman, Ann M Bode, Zigang Dong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2779450?pdf=render

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http://europepmc.org/articles/PMC2779450?pdf=render

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