Stemness‐related genes revealed by single‐cell profiling of naïve and stimulated human CD34+ cells from CB and mPB

Stemness‐related genes revealed by single‐cell profiling of naïve and stimulated human CD34+ cells from CB and mPB

Abstract Background Hematopoietic stem cells (HSCs) from different sources show varied repopulating capacity, and HSCs lose their stemness after long‐time ex vivo culture. A deep understanding of these phenomena may provide helpful insights for HSCs. Methods Here, we applied single‐cell RNA‐seq (scR...

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Bibliographic Details
Main Authors: Guoyi Dong, Xiaojing Xu, Yue Li, Wenjie Ouyang, Weihua Zhao, Ying Gu, Jie Li, Tianbin Liu, Xinru Zeng, Huilin Zou, Shuguang Wang, Yue Chen, Sixi Liu, Hai‐Xi Sun, Chao Liu
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Clinical and Translational Medicine
Subjects:
cord blood
human hematopoietic stem cells
mobilised peripheral blood
single‐cell RNA‐seq
stemness‐related genes
Online Access:https://doi.org/10.1002/ctm2.1175

Internet

https://doi.org/10.1002/ctm2.1175

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