Decreased RNA polymerase III subunit expression leads to defects in oligodendrocyte development

Decreased RNA polymerase III subunit expression leads to defects in oligodendrocyte development

IntroductionRNA polymerase III (Pol III) is a critical enzymatic complex tasked with the transcription of ubiquitous non-coding RNAs including 5S rRNA and all tRNA genes. Despite the constitutive nature of this enzyme, hypomorphic biallelic pathogenic variants in genes encoding subunits of Pol III l...

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Bibliographic Details
Main Authors: Julia Macintosh, Mackenzie Michell-Robinson, Xiaoru Chen, Geneviève Bernard
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Neuroscience
Subjects:
RNA polymerase III
leukodystrophy
oligodendrogenesis
glia
hypomyelination
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1167047/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1167047/full

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