Succinate signaling attenuates high-fat diet-induced metabolic disturbance and intestinal barrier dysfunction

Succinate signaling attenuates high-fat diet-induced metabolic disturbance and intestinal barrier dysfunction

Succinate is a vital signaling metabolite produced by the host and gut microbiota. Succinate has been shown to regulate host metabolic homeostasis and inhibit obesity-associated inflammation in macrophages by engaging its cognate receptor, SUCNR1. However, the contribution of the succinate-SUCNR1 ax...

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Bibliographic Details
Main Authors: Xuan Li, Guowen Huang, Yanan Zhang, Yuting Ren, Ruofan Zhang, Weiyun Zhu, Kaifan Yu
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Pharmacological Research
Subjects:
Succinate
SUCNR1
Obesity
Intestinal barrier
Inflammation
Microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823002219

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http://www.sciencedirect.com/science/article/pii/S1043661823002219

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