A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis

A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis

Purpose The work aimed to develop a co-loaded loratadine and sulpiride nasal nanoemulsion for allergic rhinitis management. Methods Compatibility studies were conducted adopting differential scanning calorimetry and Fourier transform infrared spectroscopy. Nanoemulsion formulations were prepared usi...

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Bibliographic Details
Main Authors: Soad A. Mohamad, Mohamed A. Safwat, Mahmoud Elrehany, Sherif A. Maher, Ahmed M. Badawi, Heba F. Mansour
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Drug Delivery
Subjects:
loratadine
sulpiride
nasal
nanoemulsion
rhinitis
Online Access:http://dx.doi.org/10.1080/10717544.2021.1872741

Internet

http://dx.doi.org/10.1080/10717544.2021.1872741

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