Transgenic HA-1-Specific CD8<sup>+</sup> T-Lymphocytes Selectively Target Leukemic Cells

Transgenic HA-1-Specific CD8<sup>+</sup> T-Lymphocytes Selectively Target Leukemic Cells

A significant share of allogeneic hematopoietic stem cell transplantations (allo-HSCT) results in the relapse of malignant disease. The T cell immune response to minor histocompatibility antigens (MiHAs) promotes a favorable graft-versus-leukemia response. The immunogenic MiHA HA-1 is a promising ta...

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Bibliographic Details
Main Authors: Artem Pilunov, Dmitrii S. Romaniuk, Anton Shmelev, Savely Sheetikov, Anna N. Gabashvili, Alexandra Khmelevskaya, Dmitry Dianov, Ksenia Zornikova, Naina T. Shakirova, Murad Vagida, Apollinariya Bogolyubova, Grigory A. Efimov
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
adoptive transfer
acute myeloid leukemia
transgenic TCR
allo-HSCT
minor histocompatibility antigens
HA-1
Online Access:https://www.mdpi.com/2072-6694/15/5/1592

Internet

https://www.mdpi.com/2072-6694/15/5/1592

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