Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study

Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study

Abstract Amyotrophic Lateral Sclerosis (ALS) is mainly characterized by the degeneration of corticospinal neurons and spinal α-motoneurons; vulnerable cells display prominent pTDP-43 inclusions. Evidence gathered from genetics, murine models, and iPSC-derived neurons point to the early involvement o...

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Bibliographic Details
Main Authors: Oumayma Aousji, Simone Feldengut, Stefano Antonucci, Michael Schön, Tobias M. Boeckers, Jakob Matschke, Christian Mawrin, Albert C. Ludolph, Kelly Del Tredici, Francesco Roselli, Heiko Braak
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Phosphorylated TDP-43 (pTDP-43)
Human spinal cord
Synaptic loss
Synaptophysin
Online Access:https://doi.org/10.1186/s40478-023-01616-8

Internet

https://doi.org/10.1186/s40478-023-01616-8

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