A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

Centrosome clustering allows survival of cells with amplified centrosomes at the cost of chromosome instability. Here, Chavali et al. show that the centrosome component CEP215 collaborates with the kinesin motor HSET both to maintain spindle poles connections and to cluster centrosomes.

Bibliographic Details
Main Authors: Pavithra L. Chavali, Gayathri Chandrasekaran, Alexis R. Barr, Péter Tátrai, Chris Taylor, Evaggelia K. Papachristou, C. Geoffrey Woods, Sreenivas Chavali, Fanni Gergely
Format: Article
Language:English
Published: Nature Portfolio 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11005

Internet

https://doi.org/10.1038/ncomms11005

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