Klotho‐mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments

Klotho‐mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments

Senescent microenvironments play an important role in tumor progression. Here, we report that doxorubicin (DOX)‐pretreated or replicative senescent stromal cells (WI‐38 and HUVEC) promote colorectal cancer (CRC) cell growth and invasion in vitro and in vivo. These pro‐tumorigenic effects were attenu...

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Bibliographic Details
Main Authors: Yangyang Liu, Jie Pan, Xia Pan, Lunpo Wu, Jun Bian, Zhenghua Lin, Meng Xue, Tingting Su, Sanchuan Lai, Fei Chen, Qiwei Ge, Luyi Chen, Shufang Ye, Yabi Zhu, Shujie Chen, Liangjing Wang
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Molecular Oncology
Subjects:
CCL2
colorectal cancer
Klotho
senescence
Online Access:https://doi.org/10.1002/1878-0261.12577

Internet

https://doi.org/10.1002/1878-0261.12577

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