Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion

Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion

The bioavailability of copper (Cu) in human cells may depend on a complex interplay with zinc (Zn) ions. We investigated the ability of the Zn ion to target the human Cu-chaperone Atox1, a small cytosolic protein capable of anchoring Cu(I), by a conserved surface-exposed Cys-X-X-Cys (CXXC) motif, an...

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Bibliographic Details
Main Authors: Vincenzo Mangini, Benny Danilo Belviso, Maria Incoronata Nardella, Giovanni Natile, Fabio Arnesano, Rocco Caliandro
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
X-ray crystallography
molecular structure
metal ions
zinc
copper transport proteins
metallochaperones
Online Access:https://www.mdpi.com/2218-273X/12/10/1494

Internet

https://www.mdpi.com/2218-273X/12/10/1494

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