Inter-channel scaffolding of presynaptic CaV2.2 via the C terminal PDZ ligand domain

Summary Calcium entry through CaV2.2 calcium channels clustered at the active zone (AZ) of the presynaptic nerve terminal gates synaptic vesicle (SV) fusion and the discharge of neurotransmitters, but the mechanism of channel scaffolding remains poorly understood. Recent studies have implicated the...

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Bibliographic Details
Main Authors: Sabiha R. Gardezi, Qi Li, Elise F. Stanley
Format: Article
Language:English
Published: The Company of Biologists 2013-04-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/2/5/492