JNKs protect from cholestatic liver disease progression by modulating Apelin signalling

JNKs protect from cholestatic liver disease progression by modulating Apelin signalling

Background & Aims: Cholestatic liver injury is associated with c-Jun N-terminal kinases (JNK) activation in distinct cell types. Its hepatocyte-specific function during cholestasis, however, has not yet been established. Therefore, in our present study, we investigated the role of JNK1/2 dur...

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Bibliographic Details
Main Authors: Mohamed Ramadan Mohamed, Johannes Haybaeck, Hanghang Wu, Huan Su, Matthias Bartneck, Cheng Lin, Mark V. Boekschoten, Peter Boor, Benjamin Goeppert, Christian Rupp, Pavel Strnad, Roger J. Davis, Francisco Javier Cubero, Christian Trautwein
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:JHEP Reports
Subjects:
c-Jun N-terminal kinases (JNK)
Cholestasis
Fibrosis
Hepatocytes
Apelin
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923001854

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http://www.sciencedirect.com/science/article/pii/S2589555923001854

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