Itaconic acid and dimethyl itaconate exert antibacterial activity in carbon-enriched environments through the TCA cycle

Itaconic acid and dimethyl itaconate exert antibacterial activity in carbon-enriched environments through the TCA cycle

Itaconic acid (IA), a metabolite generated by the tricarboxylic acid (TCA) cycle in eukaryotic immune cells, and its derivative dimethyl itaconate (DI) exert antibacterial functions in intracellular environments. Previous studies suggested that IA and DI only inhibit bacterial growth in carbon-limit...

Full description

Bibliographic Details
Main Authors: L.Y. Xie, Y.B. Xu, X.Q. Ding, S. Liang, D.L. Li, A.K. Fu, X.A. Zhan
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Itaconic acid
Dimethyl itaconate
Antibacterial activity
TCA cycle
Bacterial pathogenicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012854

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223012854

Similar Items