Drug Repurposing of the Unithiol: Inhibition of Metallo-β-Lactamases for the Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections

Drug Repurposing of the Unithiol: Inhibition of Metallo-β-Lactamases for the Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections

The increasing antibiotic resistance is a clinical problem worldwide. Numerous Gram-negative bacteria have already become resistant to the most widely used class of antibacterial drugs, β-lactams. One of the main mechanisms is inactivation of β-lactam antibiotics by bacterial β-lactamases. Appearanc...

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Bibliographic Details
Main Authors: Vitaly G. Grigorenko, Maria G. Khrenova, Irina P. Andreeva, Maya Yu. Rubtsova, Anastasia I. Lev, Tatiana S. Novikova, Elena V. Detusheva, Nadezhda K. Fursova, Ivan A. Dyatlov, Alexey M. Egorov
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
metallo-β-lactamase
drug repurposing
antibiotic resistance
molecular modeling
Online Access:https://www.mdpi.com/1422-0067/23/3/1834

Internet

https://www.mdpi.com/1422-0067/23/3/1834

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