Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays

Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays

Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining attention for the treatment of different cancer types, but also to contrast neurodegenerative disease, diabetes, and autoimmune syndromes. In the search for SIRT2 modulators, the availability of several X-crysta...

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Bibliographic Details
Main Authors: Elena Abbotto, Beatrice Casini, Francesco Piacente, Naomi Scarano, Elena Cerri, Michele Tonelli, Cecilia Astigiano, Enrico Millo, Laura Sturla, Santina Bruzzone, Elena Cichero
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceuticals
Subjects:
SIRT2
sirtuin
virtual screening
molecular docking
enzymatic assays
inhibitor
Online Access:https://www.mdpi.com/1424-8247/16/9/1316

Internet

https://www.mdpi.com/1424-8247/16/9/1316

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