Human Osteoarthritic Chondrocytes Express Nineteen Different TRP-Genes—TRPA1 and TRPM8 as Potential Drug Targets

Human Osteoarthritic Chondrocytes Express Nineteen Different TRP-Genes—TRPA1 and TRPM8 as Potential Drug Targets

Transient receptor potential (TRP) ion channels are expressed in neuronal and some non-neuronal cells and are involved particularly in pain and thermosensation. We previously showed that TRPA1 is functionally expressed in human osteoarthritic (OA) chondrocytes and mediates inflammation, cartilage de...

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Bibliographic Details
Main Authors: Leevi Halonen, Antti Pemmari, Elina Nummenmaa, Mari Hämäläinen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis
chondrocyte
TRPA1
TRPM8
TPR ion channel
glucocorticoid
Online Access:https://www.mdpi.com/1422-0067/24/12/10057

Internet

https://www.mdpi.com/1422-0067/24/12/10057

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