Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury

Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury

Pneumococcal meningitis (PM) is characterized by an intense inflammatory host reaction that contributes to the development of cortical necrosis and hippocampal apoptosis. Inflammatory conditions in the brain are known to induce tryptophan degradation along the kynurenine pathway, resulting in accumu...

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Bibliographic Details
Main Authors: Caroline L. Bellac, Roney S. Coimbra, Stephan Christen, Stephen L. Leib
Format: Article
Language:English
Published: Elsevier 2006-11-01
Series:Neurobiology of Disease
Subjects:
Neuroinflammatory diseases
Pneumococcal meningitis
Kynurenine pathway
3-Hydroxykynurenine
Neurotoxicity
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610600177X

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http://www.sciencedirect.com/science/article/pii/S096999610600177X

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