Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

Whereas VHL inactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the precise mechanism(s) of how this interacts with the secondary mutations in tumor suppressor genes, including PBRM1, KDM5C/JARID1C, SETD2, and/or BAP1, remains unclear. Gene expression analyses reveal that VHL...

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Bibliographic Details
Main Authors: Lili Liao, Zongzhi Z Liu, Lauren Langbein, Weijia Cai, Eun-Ah Cho, Jie Na, Xiaohua Niu, Wei Jiang, Zhijiu Zhong, Wesley L Cai, Geetha Jagannathan, Essel Dulaimi, Joseph R Testa, Robert G Uzzo, Yuxin Wang, George R Stark, Jianxin Sun, Stephen Peiper, Yaomin Xu, Qin Yan, Haifeng Yang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
kidney cancer
VHL
PBRM1
KDM5C
BAP1
ISGF3
Online Access:https://elifesciences.org/articles/37925

Internet

https://elifesciences.org/articles/37925

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