Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the p53/p21/CDK1 Signaling Pathway

Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the p53/p21/CDK1 Signaling Pathway

Spinal cord injury (SCI) is a catastrophic event mainly involving neuronal apoptosis and axonal disruption, and it causes severe motor and sensory deficits. Due to the complicated pathological process of SCI, there is currently still a lack of effective treatment for SCI. Microglia, a type of immune...

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Bibliographic Details
Main Authors: Chengjun Li, Tian Qin, Yudong Liu, Haicheng Wen, Jinyun Zhao, Zixiang Luo, Wei Peng, Hongbin Lu, Chunyue Duan, Yong Cao, Jianzhong Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
microglia
spinal cord injury
neuronal apoptosis
exosomes
miR-151-3p
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.783017/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.783017/full

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