Severe traumatic injury is associated with profound changes in DNA methylation

Abstract Whether DNA methylation changes follow human physical trauma is uncertain. We aimed to investigate if severe trauma was associated with DNA methylation changes. In a prospective, observational, clinical study, we included severely injured adults and adults undergoing elective surgery (contr...

Full description

Bibliographic Details
Main Authors: Trine O. Eskesen, Kristian Almstrup, Laurits Elgaard, Tobias Arleth, Mathilde L. Lassen, Andreas Creutzburg, Alice Herrlin Jensen, Niklas Breindahl, Felicia Dinesen, Malene Vang, Erik Sørensen, Anders Wallin Paulsen, Tatiana Nielsen, Lars S. Rasmussen, Martin Sillesen, Jacob Steinmetz
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-024-00438-4