YM115, A PHARMACOLOGICAL SUPPRESSANT OF SURVIVIN/XIAP, EXHIBITS ANTINEOPLASTIC ACTIVITY IN JAK2V617F CELLS
Objective: The central role of the control of apoptosis in the pathophysiology of Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) has been recently reinforced in genetic and pharmacological studies. The inhibitor of apoptosis protein (IAP) family has eight members and plays an im...
Main Authors: | JAEG Carlos, K Lima, EM Rego, LV Cost-Lotufo, JA Machad-Neto |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-10-01
|
Series: | Hematology, Transfusion and Cell Therapy |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137923006314 |
Similar Items
-
Survivin inhibition with YM155 ameliorates experimental pulmonary arterial hypertension
by: Isabel Blanco, et al.
Published: (2023-04-01) -
AD80 HAS ANTINEOPLASTIC EFFECTS ON HUMAN AND MURINE CML CELL MODELS
by: LBL Miranda, et al.
Published: (2023-10-01) -
Testing of the Survivin Suppressant YM155 in a Large Panel of Drug-Resistant Neuroblastoma Cell Lines
by: Martin Michaelis, et al.
Published: (2020-03-01) -
Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis
by: Grützmann Robert, et al.
Published: (2010-07-01) -
NOVEL POTENTIAL HDAC INHIBITOR INDUCES CELL DIFFERENTIATION IN ACUTE MYELOID LEUKEMIA CELLS
by: JAEG Carlos, et al.
Published: (2023-10-01)