Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury

Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury

Mechanical trauma to the spinal cord causes extensive neuronal death, contributing to the loss of sensory-motor and autonomic functions below the injury location. Apoptosis affects neurons after spinal cord injury (SCI) and is associated with increased caspase activity. Cleavage of X-linked inhibito...

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Bibliographic Details
Main Authors: David Reigada, Rodrigo M. Maza, Teresa Muñoz-Galdeano, María Asunción Barreda-Manso, Altea Soto, Dan Lindholm, Rosa Navarro-Ruíz, Manuel Nieto-Díaz
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
spinal cord injury
X-linked inhibitor of apoptosis protein
neuroprotection
apoptosis
transgenic mice
Online Access:https://www.mdpi.com/1422-0067/24/3/2791

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https://www.mdpi.com/1422-0067/24/3/2791

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