Glucocorticoid stimulation induces regionalized gene responses within topologically associating domains

Glucocorticoid stimulation induces regionalized gene responses within topologically associating domains

Transcription-factor binding to cis-regulatory regions regulates the gene expression program of a cell, but occupancy is often a poor predictor of the gene response. Here, we show that glucocorticoid stimulation led to the reorganization of transcriptional coregulators MED1 and BRD4 within topologic...

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Bibliographic Details
Main Authors: Christophe Tav, Éric Fournier, Michèle Fournier, Fatemeh Khadangi, Audrey Baguette, Maxime C. Côté, Maruhen A. D. Silveira, Félix-Antoine Bérubé-Simard, Guillaume Bourque, Arnaud Droit, Steve Bilodeau
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Genetics
Subjects:
transcription
position effects
coregulators
topologically associating domains
glucocorticoid receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1237092/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1237092/full

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