The Effect of the Stringent Response and Oxidative Stress Response on Fitness Costs of De Novo Acquisition of Antibiotic Resistance

The Effect of the Stringent Response and Oxidative Stress Response on Fitness Costs of De Novo Acquisition of Antibiotic Resistance

Resistance evolution during exposure to non-lethal levels of antibiotics is influenced by various stress responses of bacteria which are known to affect growth rate. Here, we aim to disentangle how the interplay between resistance development and associated fitness costs is affected by stress respon...

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Bibliographic Details
Main Authors: Wenxi Qi, Martijs J. Jonker, Drosos Katsavelis, Wim de Leeuw, Meike Wortel, Benno H. ter Kuile
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
de novo antibiotic resistance
fitness cost
(p)ppGpp
reactive oxygen species
compensatory evolution
Online Access:https://www.mdpi.com/1422-0067/25/5/2582

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https://www.mdpi.com/1422-0067/25/5/2582

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