Nutritional and Metabolic Factors, Ethanol and Cholesterol, Interact With Calcium-Dependent N-Methyl-D-Aspartate Receptor Inhibition by Tricyclic Antidepressants

Nutritional and Metabolic Factors, Ethanol and Cholesterol, Interact With Calcium-Dependent N-Methyl-D-Aspartate Receptor Inhibition by Tricyclic Antidepressants

It is known that overexpression of N-methyl-D-aspartate receptors (NMDARs) contributes to central sensitization and development of neuropathic pain. Tricyclic antidepressants (TCAs), amitriptyline (ATL), and desipramine (DES) exhibit analgetic anti-NMDAR activity and are commonly utilized for pain t...

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Bibliographic Details
Main Authors: Sergei I. Boikov, Dmitry A. Sibarov, Sergei M. Antonov
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
NMDA receptors
tricyclic antidepressants
amitriptyline
desipramine
clomipramine
ethanol
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.946426/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.946426/full

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