Cell-of-Origin and Genetic, Epigenetic, and Microenvironmental Factors Contribute to the Intra-Tumoral Heterogeneity of Pediatric Intracranial Ependymoma

Cell-of-Origin and Genetic, Epigenetic, and Microenvironmental Factors Contribute to the Intra-Tumoral Heterogeneity of Pediatric Intracranial Ependymoma

Intra-tumoral heterogeneity (ITH) is a complex multifaceted phenomenon that posits major challenges for the clinical management of cancer patients. Genetic, epigenetic, and microenvironmental factors are concurrent drivers of diversity among the distinct populations of cancer cells. ITH may also be...

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Bibliographic Details
Main Authors: Tiziana Servidei, Donatella Lucchetti, Pierluigi Navarra, Alessandro Sgambato, Riccardo Riccardi, Antonio Ruggiero
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
intra-tumoral heterogeneity
ependymoma
genetics
epigenetics
tumor microenvironment
cancer stem cells
Online Access:https://www.mdpi.com/2072-6694/13/23/6100

Internet

https://www.mdpi.com/2072-6694/13/23/6100

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