DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2

DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2

Abstract Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of castration-resistant prostate cancer resistant to androgen receptor (AR) inhibitors. Our study unveils that AR suppresses the neuronal development protein dihydropyrimidinase-related protein 5 (DPYSL5), providi...

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Bibliographic Details
Main Authors: Roosa Kaarijärvi, Heidi Kaljunen, Lucia Nappi, Ladan Fazli, Sonia H. Y. Kung, Jaana M. Hartikainen, Ville Paakinaho, Janne Capra, Kirsi Rilla, Marjo Malinen, Petri I. Mäkinen, Seppo Ylä-Herttuala, Amina Zoubeidi, Yuzhuo Wang, Martin E. Gleave, Mikko Hiltunen, Kirsi Ketola
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05741-x

Internet

https://doi.org/10.1038/s42003-023-05741-x

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