Measuring the effect of inter-study variability on estimating prediction error.

BACKGROUND:The biomarker discovery field is replete with molecular signatures that have not translated into the clinic despite ostensibly promising performance in predicting disease phenotypes. One widely cited reason is lack of classification consistency, largely due to failure to maintain performa...

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Bibliographic Details
Main Authors: Shuyi Ma, Jaeyun Sung, Andrew T Magis, Yuliang Wang, Donald Geman, Nathan D Price
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4201588?pdf=render