Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia

Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia

Increased levels of fetal hemoglobin (HbF) are a hallmark of more than half of the children diagnosed with juvenile myelomonocytic leukemia (JMML). Elevated HbF levels in JMML are associated with DNA hypermethylation of distinct gene promoter regions in leukemic cells. Since the regulation of globin...

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Bibliographic Details
Main Authors: Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Thomas Epting, Oliver Mücke, Christoph Plass, Charlotte M. Niemeyer, Christian Flotho
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:Epigenetics
Subjects:
epigenetic regulation
fetal hemoglobin
juvenile myelomonocytic leukemia
klf1
Online Access:http://dx.doi.org/10.1080/15592294.2017.1356959

Internet

http://dx.doi.org/10.1080/15592294.2017.1356959

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