Deleterious and protective effects of epothilone-D alone and in the context of amyloid β- and tau-induced alterations

Deleterious and protective effects of epothilone-D alone and in the context of amyloid β- and tau-induced alterations

Amyloid-β (Aβ) and hyperphosphorylated tau (P-tau) are Alzheimer’s disease (AD) biomarkers that interact in a complex manner to induce most of the cognitive and brain alterations observed in this disease. Since the neuronal cytoskeleton is a common downstream pathological target of tau and Aβ, which...

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Bibliographic Details
Main Authors: Ángel Abdiel Robles-Gómez, Benito Ordaz, Jonathan-Julio Lorea-Hernández, Fernando Peña-Ortega
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
tau and phospho-tau protein
amyloid - β
microtubule
therapeutic
epothilone-D
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1198299/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1198299/full

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