Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response

Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response

Pancreatic neuroendocrine tumors (PanNETs) comprise a heterogeneous group of tumors with growing incidence. Recent molecular analyses provided a precise picture of their genomic and epigenomic landscape. Splicing dysregulation is increasingly regarded as a novel cancer hallmark influencing key tumor...

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Bibliographic Details
Main Authors: Emilia Alors-Pérez, Sergio Pedraza-Arevalo, Ricardo Blázquez-Encinas, Víctor García-Vioque, Antonio Agraz-Doblas, Elena M. Yubero-Serrano, Marina E. Sánchez-Frías, Raquel Serrano-Blanch, María Ángeles Gálvez-Moreno, Francisco Gracia-Navarro, Manuel D. Gahete, Álvaro Arjona-Sánchez, Raúl M. Luque, Alejandro Ibáñez-Costa, Justo P. Castaño
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
Neuroendocrine tumors
PanNETs
splicing
splicing factor
CELF4
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123003086

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http://www.sciencedirect.com/science/article/pii/S2162253123003086

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