Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains

Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin gene. Emerging evidence shows that additional epigenetic factors can modify disease phenotypes. Harnessing the ability of the epigenome to modify the disease for...

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Bibliographic Details
Main Authors: Pritika Narayan, Suzanne Reid, Emma L. Scotter, Ailsa L. McGregor, Nasim F. Mehrabi, Malvindar K. Singh-Bains, Michelle Glass, Richard L.M. Faull, Russell G. Snell, Mike Dragunow
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Histone acetylation
Acetyl histone H4
Histone deacetylase inhibitors
Mutant huntingtin aggregate
Transgenic HD sheep
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303673

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http://www.sciencedirect.com/science/article/pii/S0969996120303673

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