The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells

The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells

Triple negative breast cancer (TNBC) has a high recurrence rate, metastasis rate and mortality rate. The aim of this study is to identify new targets for the treatment of TNBC. Clinical samples are used for screening deubiquitinating enzymes (DUBs). MDA-MB-231 cells and a TNBC mouse model are used f...

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Bibliographic Details
Main Authors: Huang Qidi, Zheng Shurong, Gu Huayan, Yang Zhi, Lu Yiqiao, Yu Xia, Guo Guilong
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-03-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
BRCC3
ZEB1
epithelial-mesenchymal transition
triple negative breast cancer
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024005

Internet

https://www.sciengine.com/doi/10.3724/abbs.2024005

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