Melatonin Protects Against Neuronal Apoptosis via Suppression of the ATF6/CHOP Pathway in a Rat Model of Intracerebral Hemorrhage

Melatonin Protects Against Neuronal Apoptosis via Suppression of the ATF6/CHOP Pathway in a Rat Model of Intracerebral Hemorrhage

Neuronal apoptosis is an important factor accounting for the poor outcomes of intracerebral hemorrhage (ICH). This study first showed that inhibition of activating transcription factor 6 (ATF6) could alleviate secondary brain injury through anti-apoptosis after ICH in rats. Melatonin, ATF6 and CCAAT...

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Bibliographic Details
Main Authors: Weilin Xu, Xiaoyang Lu, Jingwei Zheng, Tao Li, Liansheng Gao, Cameron Lenahan, Anwen Shao, Jianmin Zhang, Jun Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Neuroscience
Subjects:
intracerebral hemorrhage
mesencephalic astrocyte-derived neurotrophic factor (ATF6)
CCAAT/enhancer-binding protein homologous protein (CHOP)
apoptosis
secondary brain injury
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00638/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00638/full

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