Melatonin Protects Against Neuronal Apoptosis via Suppression of the ATF6/CHOP Pathway in a Rat Model of Intracerebral Hemorrhage

Melatonin Protects Against Neuronal Apoptosis via Suppression of the ATF6/CHOP Pathway in a Rat Model of Intracerebral Hemorrhage

Neuronal apoptosis is an important factor accounting for the poor outcomes of intracerebral hemorrhage (ICH). This study first showed that inhibition of activating transcription factor 6 (ATF6) could alleviate secondary brain injury through anti-apoptosis after ICH in rats. Melatonin, ATF6 and CCAAT...

Full description

Bibliographic Details
Main Authors:	Weilin Xu, Xiaoyang Lu, Jingwei Zheng, Tao Li, Liansheng Gao, Cameron Lenahan, Anwen Shao, Jianmin Zhang, Jun Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-09-01
Series:	Frontiers in Neuroscience
Subjects:	intracerebral hemorrhage mesencephalic astrocyte-derived neurotrophic factor (ATF6) CCAAT/enhancer-binding protein homologous protein (CHOP) apoptosis secondary brain injury
Online Access:	https://www.frontiersin.org/article/10.3389/fnins.2018.00638/full

Similar Items

Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study
by: Cheng-Liang Zhang, et al.
Published: (2023-06-01)

RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function
by: Fang Fang, et al.
Published: (2023-09-01)

ERH Interacts With EIF2α and Regulates the EIF2α/ATF4/CHOP Pathway in Bladder Cancer Cells
by: Kun Pang, et al.
Published: (2022-06-01)

Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression
by: Hiroki Matsumoto, et al.
Published: (2013-08-01)

Oxidized high density lipoprotein induces macrophage apoptosis via toll-like receptor 4-dependent CHOP pathway
by: Shutong Yao, et al.
Published: (2017-01-01)

Endoplasmic Reticulum Stress PERK-ATF4-CHOP Pathway Is Associated with Hypothalamic Neuronal Injury in Different Durations of Stress in Rats
by: Shanyong Yi, et al.
Published: (2017-03-01)

Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
by: Jingwei Zheng, et al.
Published: (2023-08-01)

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease
by: Pascaline Aimé, et al.
Published: (2020-03-01)

Sodium Benzoate Attenuates Secondary Brain Injury by Inhibiting Neuronal Apoptosis and Reducing Mitochondria-Mediated Oxidative Stress in a Rat Model of Intracerebral Hemorrhage: Possible Involvement of DJ-1/Akt/IKK/NFκB Pathway
by: Weilin Xu, et al.
Published: (2019-04-01)

A systems biological analysis of the ATF4‐GADD34‐CHOP regulatory triangle upon endoplasmic reticulum stress
by: Margita Márton, et al.
Published: (2022-11-01)

Induction of DR5-Dependent Apoptosis by PGA<sub>2</sub> through ATF4-CHOP Pathway
by: Kyeong-Min Park, et al.
Published: (2022-06-01)

Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage
by: Jianan Lu, et al.
Published: (2019-06-01)

Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3
by: Bo Ma, et al.
Published: (2018-09-01)

The Influence of Chopping Duration on the Degree of Proteins Extraction
by: Daniela Ianițchi, et al.
Published: (2023-10-01)

Cardioprotective effect of Ginger in a rat model of myocardial damage and its possible intervention in PERK-ATF4-CHOP-PUMA apoptotic pathway
by: M. M. Mohammed, et al.
Published: (2023-02-01)

Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway
by: Yu-Jen Wu, et al.
Published: (2013-08-01)

UPR Responsive Genes Manf and Xbp1 in Stroke
by: Helike Lõhelaid, et al.
Published: (2022-06-01)

Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson’s disease
by: Chun Yang, et al.
Published: (2020-06-01)

Effects of furosemide on PERK/eIF2α/CHOP pathway and secondary brain injury in rat models with intracerebral hemorrhage
by: ZHANG Yu, GAO Jian-zhou, HAN Shao
Published: (2022-01-01)

Gestational exposure to BDE-209 induces placental injury via the endoplasmic reticulum stress-mediated PERK/ATF4/CHOP signaling pathway
by: Yan Zhao, et al.
Published: (2022-03-01)

Apoptosis induced by mercuric chloride is associated with upregulation of PERK-ATF4-CHOP pathway in chicken embryonic kidney cells
by: Yan Ma, et al.
Published: (2020-11-01)

Endoplasmic Reticulum Stress Is Involved in Stress-Induced Hypothalamic Neuronal Injury in Rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK Pathways
by: Shanyong Yi, et al.
Published: (2019-05-01)

Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats
by: Yifang Chen, et al.
Published: (2014-06-01)

A randomized controlled trial to assess safety and efficacy between terminal chop, stop and chop, and direct chop
by: Aprajita Sinha, et al.
Published: (2023-01-01)

Calreticulin Translocation Aggravates Endoplasmic Reticulum Stress-associated Apoptosis during Cardiomyocyte Hypoxia/Reoxygenation
by: Fei-Fei Xu, et al.
Published: (2015-01-01)

Human-Specific Regulation of Neurotrophic Factors MANF and CDNF by microRNAs
by: Julia Konovalova, et al.
Published: (2021-09-01)

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma
by: Sanghwa Kim, et al.
Published: (2021-04-01)

PRDX6 inhibits hepatic stellate cells activation and fibrosis via promoting MANF secretion
by: Xiaofang Tao, et al.
Published: (2022-12-01)

Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation
by: Shen Yujun, et al.
Published: (2012-11-01)

Research Progress of Endoplasmic Reticulum Stress PERK-eIF2α-AFT4-CHOP Signaling Pathway in Hematological Malignancies
by: HE Mengke, et al.
Published: (2024-02-01)

Comparison of “Nagahara Phaco-Chop” and “Stop-And-Chop Phacoemulsification Techniques”
by: Devrim Toslak, et al.
Published: (2018-07-01)

MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects
by: Jenni E. Anttila, et al.
Published: (2024-01-01)

The effect of voluntary exercise on MANF level in the brainstem of Parkinsonian rats induced by 6-Hydroxydopamine
by: Zia Fallah-mohammadi, et al.
Published: (2014-08-01)

Comparison of power-free-chop and phaco-chop techniques for moderate nuclei
by: Lin Yao, et al.
Published: (2020-05-01)

ER Stress Activating ATF4/CHOP-TNF-α Signaling Pathway Contributes to Alcohol-Induced Disruption of Osteogenic Lineage of Multipotential Mesenchymal Stem Cell
by: Yueping Chen, et al.
Published: (2013-09-01)

Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice
by: Yasushi Ito, et al.
Published: (2009-12-01)

KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis
by: Tian F, et al.
Published: (2020-03-01)

An initial characterisation of the Unfolded Protein Response pathway in haematopoietic canine cancer cell lines – a necessary step for the future development of new therapies in dogs with neoplasia
by: Hernández-Suárez Beatriz, et al.
Published: (2023-09-01)

Comparison of press-and-chop and Nagahara phaco-chop phacoemulsification nucleotomy techniques
by: Mao Xu, et al.
Published: (2021-07-01)

Mechanism of oxymatrine-induced human esophageal cancer cell apoptosis by the endoplasmic reticulum stress pathway
by: Wang Baiyan, et al.
Published: (2018-04-01)